Extracorporeal Shockwave Therapy Data Information
Erectile Dysfunction (ED) treatment with shock waves
Erectile dysfunction (ED) is a common sexual disorder. It can be defined as the inability to achieve and/or maintain an erection sufficient for satisfactory sexual intercourse. This can have a negative effect on the quality of life of men and their partners. While most often associated with older men, ED affects a significant proportion of men, starting in middle age.
Extracorporeal shock wave therapy has been used for the treatment for erectile dysfunction (ED) of vascular origin for almost a decade. When treating ED with shock wave therapy, low-intensity shock waves are applied to different treatment zones on the penis and on the perineum (crura).
Several studies have investigated the effectiveness of low-intensity extracorporeal shock wave therapy (LiESWT) on ED. Several systematic reviews, which are the highest level of evidence according to the Oxford Centre for Evidence-based Medicine, concluded that LiESWT improves ED measured by the International Index of Erectile Function (IIEF) and Erection Hardness Score (EHS). 7,10,11,12 A systematic review over 14 studies including 833 patients stated that LiESWT »may have the potential to be the first-choice noninvasive treatment for patients with ED. 7 A prospective, randomized, double-blind, placebo-con- trolled trial 1 from 2014 showed that 57% of the men who were treated with LiESWT were able to obtain an erection after treatment and to have sexual intercourse without the use of medication. An Australian study 2 from 2015 investigated the efficacy, safety and patient satisfaction rate after LiESWT: Most patients reported an improvement in the IIEF-5 score by 5 points (60%) and in the Erectile Dysfunction Inventory of Treatment Satisfaction (EDITS) score by > 50% (70%). Most patients were satisfied (scoring 4 out of 5; 67%) and would recommend the therapy to their friends (80%). The efficacy of LiESWT has also been confirmed in animal models, for example in a study 8 published in late 2017, in which rats with a diabetes mellitus-induced ED were treated with shock waves
Extracorporeal Shockwave Therapy Data Information
1 Olsen, A. B.; Persiani, M.; Boie, S.; Hanna, M.; Lund, L.: Can low-intensity extracorporeal shockwave therapy improve erectile dysfunction? A prospective, randomized, doubleblind, placebo-controlled study, Scandinavian journal of urology, Informa Healthcare Stockholm, 2014, 1-5.
2 Chung, E.; Cartmill, R.: Evaluation of clinical efficacy, safety and patient satis- faction rate after low-intensity extracorporeal shockwave therapy for the treat- ment of male erectile dysfunction: an Australian first open-label single-arm pro- spective clinical trial, BJU international, Wiley Online Library, 2015, 115, 46-49.
3 Michel, M. S.; Ptaschnyk, T.; Musial, A.; Braun, P.; Lenz, S. T.; Alken, P.; Köhr- mann, K. U.: Objective and subjective changes in patients with Peyronie‘s dis- ease after management with shockwave therapy, Journal of endourology, Mary Ann Liebert, Inc., 2003, 17, 41-44.
4 Palmieri, A.; Imbimbo, C.; Longo, N.; Fusco, F.; Verze, P.; Mangiapia, F.; Cre- ta, M.; Mirone, V.: A first prospective, randomized, double-blind, placebocon- trolled clinical trial evaluating extracorporeal shock wave therapy for the treat- ment of Peyronie’s disease. European Urology, Elsevier, 2009, 56(2), 363-370.
5 Zimmermann, R.; Cumpanas, A.; Miclea, F.; Janetschek, Gü.: Extracorporeal shock wave therapy for the treatment of chronic pelvic pain syndrome in males: a randomised, double-blind, placebo controlled study, European urology, Else- vier, 2009, 56, 418-424.
6 Vahdatpour, B.; Alizadeh, F.; Moayednia, A.; Emadi, M.; Khorami, M. H.; Haghdani, S.: Efficacy of Extracorporeal Shock Wave Therapy for the Treatment of Chronic Pelvic Pain Syndrome: A Randomized, Controlled Trial, ISRN urology, Hindawi Publishing Corporation, 2013, 2013, 1-6.
7 Lu, Z.; Lin, G.; Reed-Maldonado, A.; Wang, C.; Lee, Y.C.; Lue, T.F.: Low-in- tensity Extracorporeal Shock Wave Treatment Improves Erectile Function: A Sys- tematic Review and Meta-analysis, European Urology, 2016, 71(2), 223-233.
8 Jeong, H.C; Jeon, S.H.; Qun, Z.G.; Kim K.S.; Choi, S.W.; Bashraheel, F.; Bae,
W.J.; Kim, S.J.; Cho, H.J.; Ha, U.S.; Hong, S.H.; Lee, J.Y.; Moon, D.G.; Kim, S.W.:
Effects of Next-Generation Low-Energy Extracorporeal Shockwave Therapy on Erectile Dysfunction in an Animal Model of Diabetes, World J Mens Health, 2017, Dec; 35(3):186-195.
9 Fojecki, G. L.; Tiessen, S.; Osther, P.J.S.: Extracorporeal shock wave therapy (ESWT) in urology: a systematic review of outcome in Peyronie’s disease, erectile dysfunction and chronic pelvic pain, World Journal of Urology, 2017, 35(1), 1-9.
10 Clavijo, R. I.; Kohn, T. P.; Kohn, J. R. & Ramasamy, R.: Effects of Low-Inten- sity Extracorporeal Shockwave Therapy on Erectile Dysfunction: A Systematic Review and Meta-Analysis, The journal of sexual medicine, 2017, 14, 27-35
11 Man, L. & Li, G.: Low-Intensity Extracorporeal Shock Wave Therapy for Erectile Dysfunction: a Systematic Review and Meta-Analysis., Urology, 2017
12 Angulo, J. C.; Arance, I.; de Las Heras, M. M.; Meilán, E.; Esquinas, C. & Andrés, E. M.: Efficacy of low-intensity shock wave therapy for erectile dysfunc- tion: A systematic review and meta-analysis. Actas urologicas espanolas, 2017, 41, 479-490
Extracorporeal shock wave therapy has been used for the treatment for erectile dysfunction (ED) of vascular origin for almost a decade. When treating ED with shock wave therapy, low-intensity shock waves are applied to different treatment zones on the penis and on the perineum (crura).
Several studies have investigated the effectiveness of low-intensity extracorporeal shock wave therapy (LiESWT) on ED. Several systematic reviews, which are the highest level of evidence according to the Oxford Centre for Evidence-based Medicine, concluded that LiESWT improves ED measured by the International Index of Erectile Function (IIEF) and Erection Hardness Score (EHS). 7,10,11,12 A systematic review over 14 studies including 833 patients stated that LiESWT »may have the potential to be the first-choice noninvasive treatment for patients with ED. 7 A prospective, randomized, double-blind, placebo-con- trolled trial 1 from 2014 showed that 57% of the men who were treated with LiESWT were able to obtain an erection after treatment and to have sexual intercourse without the use of medication. An Australian study 2 from 2015 investigated the efficacy, safety and patient satisfaction rate after LiESWT: Most patients reported an improvement in the IIEF-5 score by 5 points (60%) and in the Erectile Dysfunction Inventory of Treatment Satisfaction (EDITS) score by > 50% (70%). Most patients were satisfied (scoring 4 out of 5; 67%) and would recommend the therapy to their friends (80%). The efficacy of LiESWT has also been confirmed in animal models, for example in a study 8 published in late 2017, in which rats with a diabetes mellitus-induced ED were treated with shock waves
Extracorporeal Shockwave Therapy Data Information
1 Olsen, A. B.; Persiani, M.; Boie, S.; Hanna, M.; Lund, L.: Can low-intensity extracorporeal shockwave therapy improve erectile dysfunction? A prospective, randomized, doubleblind, placebo-controlled study, Scandinavian journal of urology, Informa Healthcare Stockholm, 2014, 1-5.
2 Chung, E.; Cartmill, R.: Evaluation of clinical efficacy, safety and patient satis- faction rate after low-intensity extracorporeal shockwave therapy for the treat- ment of male erectile dysfunction: an Australian first open-label single-arm pro- spective clinical trial, BJU international, Wiley Online Library, 2015, 115, 46-49.
3 Michel, M. S.; Ptaschnyk, T.; Musial, A.; Braun, P.; Lenz, S. T.; Alken, P.; Köhr- mann, K. U.: Objective and subjective changes in patients with Peyronie‘s dis- ease after management with shockwave therapy, Journal of endourology, Mary Ann Liebert, Inc., 2003, 17, 41-44.
4 Palmieri, A.; Imbimbo, C.; Longo, N.; Fusco, F.; Verze, P.; Mangiapia, F.; Cre- ta, M.; Mirone, V.: A first prospective, randomized, double-blind, placebocon- trolled clinical trial evaluating extracorporeal shock wave therapy for the treat- ment of Peyronie’s disease. European Urology, Elsevier, 2009, 56(2), 363-370.
5 Zimmermann, R.; Cumpanas, A.; Miclea, F.; Janetschek, Gü.: Extracorporeal shock wave therapy for the treatment of chronic pelvic pain syndrome in males: a randomised, double-blind, placebo controlled study, European urology, Else- vier, 2009, 56, 418-424.
6 Vahdatpour, B.; Alizadeh, F.; Moayednia, A.; Emadi, M.; Khorami, M. H.; Haghdani, S.: Efficacy of Extracorporeal Shock Wave Therapy for the Treatment of Chronic Pelvic Pain Syndrome: A Randomized, Controlled Trial, ISRN urology, Hindawi Publishing Corporation, 2013, 2013, 1-6.
7 Lu, Z.; Lin, G.; Reed-Maldonado, A.; Wang, C.; Lee, Y.C.; Lue, T.F.: Low-in- tensity Extracorporeal Shock Wave Treatment Improves Erectile Function: A Sys- tematic Review and Meta-analysis, European Urology, 2016, 71(2), 223-233.
8 Jeong, H.C; Jeon, S.H.; Qun, Z.G.; Kim K.S.; Choi, S.W.; Bashraheel, F.; Bae,
W.J.; Kim, S.J.; Cho, H.J.; Ha, U.S.; Hong, S.H.; Lee, J.Y.; Moon, D.G.; Kim, S.W.:
Effects of Next-Generation Low-Energy Extracorporeal Shockwave Therapy on Erectile Dysfunction in an Animal Model of Diabetes, World J Mens Health, 2017, Dec; 35(3):186-195.
9 Fojecki, G. L.; Tiessen, S.; Osther, P.J.S.: Extracorporeal shock wave therapy (ESWT) in urology: a systematic review of outcome in Peyronie’s disease, erectile dysfunction and chronic pelvic pain, World Journal of Urology, 2017, 35(1), 1-9.
10 Clavijo, R. I.; Kohn, T. P.; Kohn, J. R. & Ramasamy, R.: Effects of Low-Inten- sity Extracorporeal Shockwave Therapy on Erectile Dysfunction: A Systematic Review and Meta-Analysis, The journal of sexual medicine, 2017, 14, 27-35
11 Man, L. & Li, G.: Low-Intensity Extracorporeal Shock Wave Therapy for Erectile Dysfunction: a Systematic Review and Meta-Analysis., Urology, 2017
12 Angulo, J. C.; Arance, I.; de Las Heras, M. M.; Meilán, E.; Esquinas, C. & Andrés, E. M.: Efficacy of low-intensity shock wave therapy for erectile dysfunc- tion: A systematic review and meta-analysis. Actas urologicas espanolas, 2017, 41, 479-490
Further Studies
- Initial experience with linear focused shockwave treatment for erectile dysfunction: a 6-month follow-up pilot study Y Reisman, A Hind, A Varaneckas, I Motil - International Journal of …, 2015 - nature.com
- Effectiveness of low intensity extracorporeal shock wave therapy on patients with erectile dysfunction (ED) who have failed to respond to PDE5i therapy. A pilot …A Bechara, A Casabé, W De Bonis, J Nazar - Arch Esp Urol, 2015 - restoris.
- Extracorporeal shock wave therapy (ESWT) in urology: a systematic review of outcome in Peyronie’s disease, erectile dysfunction and chronic pelvic pain. Grzegorz Lukasz Fojecki, Stefan Tiessen & Palle Jörn Sloth Osther World Journal of Urology volume 35, pages 1–9(2017)
- Comparison of the effects of extracorporeal shock wave therapy and a vacuum erectile device on penile erectile dysfunction: a randomized clinical trial. Qi T1, Ye L, Wang B, Zhang B, Chen J.
- Vardi Y., Appel B., Jacob G., Massarwi O., Gruenwald I. (2010) Can low-intensity extracorporeal shockwave therapy improve erectile function? A 6-month follow-up pilot study in patients with organic erectile dysfunction. Eur Urol 58: 243–248 [PubMed]
- Vardi Y., Appel B., Kilchevsky A., Gruenwald I. (2012) Does low intensity extracorporeal shock wave therapy have a physiological effect on erectile function? Short-term results of a randomized, double-blind, sham controlled study. J Urol 187: 1769–1775 [PubMed]
- Vasyuk Y., Hadzegova A., Shkolnik E., Kopeleva M., Krikunova O., Iouchtchouk E., et al. (2010) Initial clinical experience with extracorporeal shock wave therapy in treatment of ischemic heart failure. Congestive Heart Failure 16: 226–230 [PubMed]