TestoGain™ supports the natural production of testosterone and other androgens
TestoGain™ is a Hormone Specific™ Formulation of adaptogens and phytochemicals that support androgen signaling through a variety of mechanisms. This formula is designed to help to support the health of testosterone-producing glands and testosterone-responsive tissues.
This is accomplished by supporting the function of testosterone producing glands in both gender, and by supporting the function of testosterone tissues through the use of herbs that mimic the actions of testosterone. This natural supplement works to:
• Promotes optimal vitality, sense of well being & mood. • Supports healthy sexual function in men and women. • Promote production of testosterone by gonadal tissue in both genders • Contains herbs that protects prostate tissue in men and decreases ovarian cysts in women • Favourably affects androgen receptors, supporting healthy testosterone function • Promotes healthy function of bone, heart, brain, muscles and other testosterone responsive tissues • Enhanced stamina and general strengthening • May use without testosterone, or with bioidentical testosterone to support healthy testosterone function. • Promote production of other androgens by adrenal glands. |
How to Make Testosterone

Making Testosterone
The hypothalamic-pituitary-gonadal (HPG) axis stimulates the production of testosterone by hypothalamic-pituitary release of luteinizing hormone (LH). In men, LH stimulates the Leydig cells in the testes to produce testosterone. In women, LH stimulates theca cells in the ovaries to produce testosterone, (which the ovaries can also use as a precursor for estradiol production.
Over half of the herbs in TestoGainTM have been documented to increase testosterone levels. Some of those herbs also increase LH and/or FSH production.
How Testosterone Works
Testosterone interacts with testosterone receptors to instruct cells throughout the body to react to the testosterone. Different cells will react in different ways. Muscle cells will increase the amount of protein, due to the anabolic actions of testosterone. Nerve cells in the brain may increase the amount of dopamine (a neurotransmitter that increases motivation and drive), due to the dopaminergic actions of testosterone. Cells that line blood vessels may increase nitric oxide due to the nitric oxide stimulating affects of testosterone.
Making Testosterone Work Better
In addition to herbs that increase testosterone production, TestoGain™ has herbs that improve the function of testosterone. These herbs may be called phytoandrogens, or testosterone mimetics, which mimic one or more of the properties of testosterone. They may have anabolic, androgenic, dopaminergic
or nitric oxide properties. Some herbs act as a coactivator, which helps the testosterone receptor complex bind with DNA.
Who Should Use TestoGain
TestoGain™ was designed to increase the natural production of testosterone in men by promoting the Leydig cells in the testes to produce testosterone, and in women by promoting the theca cells in the ovaries to produce testosterone. TestoGain also contains herbs that mimic specific actions of testosterone and act as testosterone agonists, to support the health of tissues that respond to testosterone. TestoGain™ may be used instead of testosterone replacement therapy in both men and women. Or, it may be used with testosterone replacement therapy (TRT), to improve the safety and effectiveness of TRT in both men and women. The formulation was designed to serve a broad scope of patients:
• Men or women who do not want to use Testosterone Replacement Therapy (TRT). Both men and women who want to avoid TRT to avoid the risks associated with TRT can use TestoGain™.
• Men or women who are on Testosterone Replacement Therapy (TRT) who still have symptoms. Many patients on TRT still have symptoms of low testosterone even though their lab tests confirm optimal testosterone levels. This is often due to testosterone receptor resistance that develops in some patients on TRT. Testosterone receptor resistance is common in patients with a history of excessive use of testosterone. To safely raise endogenous testosterone production and also have regular intake of herbs that protect prostate tissue.
• Men or women on TRT who want to decrease side effects & risks associated with TRT – TestoGain™ is taken by patients on TRT to decrease concerns about increased risk of testosterone side effects. Maca protects prostate tissue in men, while Tribulus terrestris decreases ovarian cysts in women.
• Men or women who want to wean off of TRT can use TestoGain™ a month before weaning off of TRT to successfully wean off of TRT without symptoms of testosterone withdrawal.
• Use in Menopause Types® 2, 5, 8 & 11. For perimenopause, menopause & postmenopause.
Synergy of Phytotherapeutic Agents in TestoGain™
The unique formulation of herbs in TestoGain™ is used to both increase testosterone production and improve testosterone function. This is achieved by formulating the herbs to achieve the ultimate benefit from each herb. Just as important, the herbs are formulated in such a way that they intensify and balance the action of the other herbs. To accomplish this properly, the herbs in TestoGain™ are formulated in such a way that testosterone synergy is fully supported. In synergy, the combined interaction of different herbs produces a total effect that is greater than the sum of the individual herbs. Synergy comes from the Greek word synergos (συνεργός), which means “working together”.
Hormone Specific Formulations
TestoGain™ is a Hormone Specific Formulation formulated by Dr Joseph J Collins, RN, ND, an internationally recognized pioneer and leader in the personalized restoration of hormone health through the use of phytotherapeutics. Hormone Specific Formulations include AdrenoMend™, ThyroMend™, TestoGain™, EstroMend™, ProgestoMend™, TestoQuench™ for Men, and TestoQuench for Women. Dr Collins is the author of Discover Your Menopause Type, the first book to define the various presentations of menopause and to reveal there are different menopause types®.
All information provided in this Professional Guide is the opinion of the author and does not express or represent the
opinion of any other party. Information and statements regarding products have not been evaluated by the Food and Drug Administration and are not intended to diagnose, treat, cure, or prevent any disease.
The hypothalamic-pituitary-gonadal (HPG) axis stimulates the production of testosterone by hypothalamic-pituitary release of luteinizing hormone (LH). In men, LH stimulates the Leydig cells in the testes to produce testosterone. In women, LH stimulates theca cells in the ovaries to produce testosterone, (which the ovaries can also use as a precursor for estradiol production.
Over half of the herbs in TestoGainTM have been documented to increase testosterone levels. Some of those herbs also increase LH and/or FSH production.
How Testosterone Works
Testosterone interacts with testosterone receptors to instruct cells throughout the body to react to the testosterone. Different cells will react in different ways. Muscle cells will increase the amount of protein, due to the anabolic actions of testosterone. Nerve cells in the brain may increase the amount of dopamine (a neurotransmitter that increases motivation and drive), due to the dopaminergic actions of testosterone. Cells that line blood vessels may increase nitric oxide due to the nitric oxide stimulating affects of testosterone.
Making Testosterone Work Better
In addition to herbs that increase testosterone production, TestoGain™ has herbs that improve the function of testosterone. These herbs may be called phytoandrogens, or testosterone mimetics, which mimic one or more of the properties of testosterone. They may have anabolic, androgenic, dopaminergic
or nitric oxide properties. Some herbs act as a coactivator, which helps the testosterone receptor complex bind with DNA.
Who Should Use TestoGain
TestoGain™ was designed to increase the natural production of testosterone in men by promoting the Leydig cells in the testes to produce testosterone, and in women by promoting the theca cells in the ovaries to produce testosterone. TestoGain also contains herbs that mimic specific actions of testosterone and act as testosterone agonists, to support the health of tissues that respond to testosterone. TestoGain™ may be used instead of testosterone replacement therapy in both men and women. Or, it may be used with testosterone replacement therapy (TRT), to improve the safety and effectiveness of TRT in both men and women. The formulation was designed to serve a broad scope of patients:
• Men or women who do not want to use Testosterone Replacement Therapy (TRT). Both men and women who want to avoid TRT to avoid the risks associated with TRT can use TestoGain™.
• Men or women who are on Testosterone Replacement Therapy (TRT) who still have symptoms. Many patients on TRT still have symptoms of low testosterone even though their lab tests confirm optimal testosterone levels. This is often due to testosterone receptor resistance that develops in some patients on TRT. Testosterone receptor resistance is common in patients with a history of excessive use of testosterone. To safely raise endogenous testosterone production and also have regular intake of herbs that protect prostate tissue.
• Men or women on TRT who want to decrease side effects & risks associated with TRT – TestoGain™ is taken by patients on TRT to decrease concerns about increased risk of testosterone side effects. Maca protects prostate tissue in men, while Tribulus terrestris decreases ovarian cysts in women.
• Men or women who want to wean off of TRT can use TestoGain™ a month before weaning off of TRT to successfully wean off of TRT without symptoms of testosterone withdrawal.
• Use in Menopause Types® 2, 5, 8 & 11. For perimenopause, menopause & postmenopause.
Synergy of Phytotherapeutic Agents in TestoGain™
The unique formulation of herbs in TestoGain™ is used to both increase testosterone production and improve testosterone function. This is achieved by formulating the herbs to achieve the ultimate benefit from each herb. Just as important, the herbs are formulated in such a way that they intensify and balance the action of the other herbs. To accomplish this properly, the herbs in TestoGain™ are formulated in such a way that testosterone synergy is fully supported. In synergy, the combined interaction of different herbs produces a total effect that is greater than the sum of the individual herbs. Synergy comes from the Greek word synergos (συνεργός), which means “working together”.
Hormone Specific Formulations
TestoGain™ is a Hormone Specific Formulation formulated by Dr Joseph J Collins, RN, ND, an internationally recognized pioneer and leader in the personalized restoration of hormone health through the use of phytotherapeutics. Hormone Specific Formulations include AdrenoMend™, ThyroMend™, TestoGain™, EstroMend™, ProgestoMend™, TestoQuench™ for Men, and TestoQuench for Women. Dr Collins is the author of Discover Your Menopause Type, the first book to define the various presentations of menopause and to reveal there are different menopause types®.
All information provided in this Professional Guide is the opinion of the author and does not express or represent the
opinion of any other party. Information and statements regarding products have not been evaluated by the Food and Drug Administration and are not intended to diagnose, treat, cure, or prevent any disease.